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Teething is the process by which an infant's first teeth (the deciduous teeth, often called "baby teeth" or "milk teeth") appear by emerging through the gums, typically arriving in pairs. The mandibular central incisors are the first primary teeth to erupt, usually between 6 and 10 months of age and usually causes discomfort and pain to the infant. It can take several years for all 20 teeth to complete the
tooth eruption Tooth eruption is a process in tooth development in which the teeth enter the mouth and become visible. It is currently believed that the periodontal ligament plays an important role in tooth eruption. The first human teeth to appear, the deciduo ...
. Though the process of teething is sometimes referred to as "cutting teeth", when teeth emerge through the gums they do not cut through the flesh. Instead, hormones are released within the body that cause some cells in the gums to die and separate, allowing the teeth to come through. Teething may cause a slightly elevated temperature, but not rising into the
fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...
range of greater than . Higher temperatures during teething are due to some form of infection, such as a herpes virus, initial infection of which is extremely widespread among children of teething age.


Signs and symptoms

The level of pain that a baby can handle will be different for each child. Some may appear to suffer more than others while they are teething. The soreness and swelling of the
gums The gums or gingiva (plural: ''gingivae'') consist of the mucosal tissue that lies over the mandible and maxilla inside the mouth. Gum health and disease can have an effect on general health. Structure The gums are part of the soft tissue lin ...
before a tooth comes through is the cause for the pain and fussiness a baby experiences during this change. These symptoms usually begin about three to five days before the tooth shows, and they disappear as soon as the tooth breaks the skin. Some babies are not even bothered by teething. Common symptoms include
drooling Drooling, or slobbering, is the flow of saliva outside the mouth. Drooling can be caused by excess production of saliva, inability to retain saliva within the mouth (incontinence of saliva), or problems with swallowing (dysphagia or odynophagia ...
or dribbling, increased
chew Chewing or mastication is the process by which food is crushed and ground by teeth. It is the first step of digestion, and it increases the surface area of foods to allow a more efficient break down by enzymes. During the mastication process, ...
ing, mood changes, irritability or crankiness, and swollen gums. Crying, sleeplessness, restless sleep at night, and mild fever are also associated with teething. Teething can begin as early as 3 months and continue until a child's third birthday. In rare cases, an area can be filled with fluid and appears over where a tooth is erupting and cause the gums to be even more sensitive. Pain is often associated more with large molars since they cannot penetrate through the gums as easily as the other teeth. Some noticeable symptoms that a baby has entered the teething stage include chewing on their fingers or toys to help relieve pressure on their gums. Babies might also refuse to eat or drink due to the pain. Symptoms will generally fade on their own, but a doctor should be notified if they worsen or are persistent. Teething may cause signs and symptoms in the mouth and gums, but does not cause problems elsewhere in the body. Pulling on the ears is another sign of pain; the pain in the mouth throbs throughout the baby's head so they pull their ears believing that it will provide relief. Mild
rash A rash is a change of the human skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, c ...
can develop around the mouth due to skin irritation that is caused by excessive drooling or dribbling.


Sequence of appearance

The infant teeth tend to emerge in pairs – first one lower incisor emerges then the other lower incisor emerges before the next set begin to emerge. The general pattern of emergence is: # Lower central
incisor Incisors (from Latin ''incidere'', "to cut") are the front teeth present in most mammals. They are located in the premaxilla above and on the mandible below. Humans have a total of eight (two on each side, top and bottom). Opossums have 18, wher ...
s (2) at approximately 6 months # Upper central incisors (2) at approximately 8 months # Upper lateral incisors (2) at approximately 10 months # Lower lateral incisors (2) at approximately 10 months # First molars (4) at approximately 14 months #
Canines Canine may refer to: Zoology and anatomy * a dog-like Canid animal in the subfamily Caninae ** ''Canis'', a genus including dogs, wolves, coyotes, and jackals ** Dog, the domestic dog * Canine tooth, in mammalian oral anatomy People with the surn ...
(4) at approximately 18 months # Second molars (4) at approximately 2–3 years Milk teeth tend to emerge sooner in females than in males. The exact pattern and initial starting times of teething appear to be hereditary. When and how teeth appear in an infant has no bearing on the health of the child.


Misdiagnosis as teething

Teething has not been shown to cause fever or diarrhea; however, the belief that teething causes fever is extremely common among parents. Whilst there is some evidence that teething can cause an elevated temperature, it does not cause fever (medically defined as rectal temperature greater than . One small 1992 study found a significant rise in temperature on the day of eruption of the first tooth. Another study in 2000 found "mild temperature elevation" but not fever over . There is a risk that fever around the age of teething is dismissed as due to teething when it is actually due to illness, particularly infection by herpes viruses. "Coincidentally, primary tooth eruption begins at about the time that infants are losing maternal antibody protection against the herpes virus. Also, reports on teething difficulties have recorded symptoms which are remarkably consistent with primary oral herpetic infection such as fever, irritability, sleeplessness, and difficulty with eating." "Younger infants with higher residual levels of antibodies would experience milder infections and these would be more likely to go unrecognized or be dismissed as teething difficulty." Herpes virus infection may take the form of
primary herpetic gingivostomatitis Gingivostomatitis is a combination of gingivitis and stomatitis, or an inflammation of the oral mucosa and gingiva. Herpetic gingivostomatitis is often the initial presentation during the first ("primary") herpes simplex infection. It is of greate ...
(HSV-1) or of infection by
human herpesvirus 6 Human herpesvirus 6 (HHV-6) is the common collective name for '' human betaherpesvirus 6A'' (HHV-6A) and '' human betaherpesvirus 6B'' (HHV-6B). These closely related viruses are two of the nine known herpesviruses that have humans as their prim ...
(HHV-6), which infects 90% of children by age 2. "The symptoms of elevated temperature and facial rash could be explainable by infection with the HHV-6 agent, which is ubiquitous among infants of teething age." Other viruses may also cause fevers which may be misattributed to teething, but the oral involvement that may occur with herpes viruses makes misdiagnosis a particular risk for such infections.


Treatment

Infants may chew on objects to aid in the teething process. Teething necklaces or bracelets are not recommended as they can cause
choking Choking, also known as foreign body airway obstruction (FBAO), is a phenomenon that occurs when breathing is impeded by a blockage inside of the respiratory tract. An obstruction that prevents oxygen from entering the lungs results in oxygen dep ...
,
strangulation Strangling is compression of the neck that may lead to unconsciousness or death by causing an increasingly hypoxic state in the brain. Fatal strangling typically occurs in cases of violence, accidents, and is one of two main ways that hangin ...
, or irritation of the mouth. Teething rings and other toys, called
teether A teether, teething toy, or chew toy is a device given to teething infants. Most modern teethers are silicone, but can also be made of wood or rubber. Some teethers are filled with a fluid or gel that can be frozen or refrigerated. They differ fr ...
s, are often designed with textures. Some infants gain relief from chewing on cold objects. Some people freeze small chunks of fresh fruits or vegetables and put them in teething nets.


Medication

In cases where the infant is in obvious pain, some doctors recommend the use of
non-steroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...
s (NSAIDs) or child-safe pain-relief treatments containing benzocaine, lidocaine, or
choline salicylate Choline is an essential nutrient for humans and many other animals. Choline occurs as a cation that forms various salts (X− in the depicted formula is an undefined counteranion). Humans are capable of some ''de novo synthesis'' of choline but ...
. Benzocaine must be used cautiously because it can cause methemoglobinemia; choline salicylate is related to
aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
and "may cause
Reye's syndrome Reye syndrome is a rapidly worsening encephalopathy, brain disease. Symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. While hepatotoxicity, liver toxicity typically occurs in the ...
in susceptible children, especially those with or recovering from viral infections, or when used in combination with other NSAIDs". 5% lidocaine gel produces
anaesthesia Anesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), a ...
(numbing) within 2–5 minutes, lasting for 10–20 minutes. However, one author concludes that, "Overall, the risks and adverse effects from inappropriate or prolonged use of pharmacological agents outweigh their potential benefits." She points out that "the psychological trauma involved in administering medications or applying topical preparations to infants must be considered", and argues that "the placebo effect must not be overlooked. For example, applying a gel of 20% benzocaine in
polyethylene glycol Polyethylene glycol (PEG; ) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular we ...
may give only a modest benefit over applying the placebo, which gives an efficacy of 60% compared with 90% for the active preparation." Medicines are often applied to the babies' gums to relieve swelling and pain. These gels are similar to the toothache gel that is used by adults for sore gums and toothaches, but is administered in much smaller doses. Teething gels work as a numbing agent to dull the nerves in the gums so that the pain is less noticeable. It is important to follow the directions on the package to ensure that the correct amount of medication is administered and that proper techniques are used to reduce the risk for infection. It is important not to let the medicine numb the throat as it may interfere with the normal gag reflex and may make it possible for food to enter the lungs. Similar medicines are also available in powder form, as "teething powder". Acetaminophen and ibuprofen are also recommended to treat the pain and swelling that babies experience. It should only be used a few times a day so that it does not mask symptoms that are being experienced due to other medical conditions and not because of teething. Products that contain
aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
should never be given to a child unless directed by a pediatrician, due to the risk of
Reye's syndrome Reye syndrome is a rapidly worsening encephalopathy, brain disease. Symptoms of Reye syndrome may include vomiting, personality changes, confusion, seizures, and loss of consciousness. While hepatotoxicity, liver toxicity typically occurs in the ...
. Some traditional medicine used to treat teething pain has been found to be harmful due to high lead content, with effects including
toxic encephalopathy Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse ef ...
. "Surma" or "
kohl Kohl may refer to: *Kohl (cosmetics), an ancient eye cosmetic *Kohl (surname), including a list of people with the surname *Kohl's Kohl's (stylized in all caps) is an American department store retail chain, operated by Kohl's Corporation. ...
" has traditionally been used in the Middle East and Indian subcontinent as a teething powder, as have the Middle Eastern "saoott"/"cebagin". "Santrinj" - a 98%
lead oxide Lead oxides are a group of inorganic compounds with formulas including lead (Pb) and oxygen (O). Common lead oxides include: * Lead(II) oxide, PbO, litharge (red), massicot (yellow) * Lead(II,IV) oxide Lead(II,IV) oxide, also called red lead o ...
product otherwise used as a paint primer - is also used in the Middle East as a home remedy for teething.


History

Teething used to be considered (wrongly) a cause of death, as many children died in the first years of life, at the same time as teething occurs. "The tendency in the past to attribute serious disease to teething was so prevalent that in 1842 teething was the registered cause of death in 4.8% of all infants who died in London under the age of 1 year and 7.3% of those between the ages of 1 to 3 years according to the Registrar General's report." Ironically, while teething is a natural process which creates little more than discomfort, some methods for relieving teething pain have caused serious harm and even death. Old remedies for teething include "blistering, bleeding, placing leeches on the gums, and applying cautery to the back of the head". In the sixteenth century the French surgeon Ambroise Paré introduced the lancing of gums using a lancet, in the belief that teeth were failing to emerge from the gums due to lack of a pathway, and that this failure was a cause of death. This belief and practice persisted for centuries, with some exceptions, until towards the end of the nineteenth century lancing became increasingly controversial and was then abandoned, although as late as 1938 an Anglo-American dental textbook advised in favour of lancing, and described the procedure. In the first half of the twentieth century, teething powders in the English-speaking world often contained
calomel Calomel is a mercury chloride mineral with formula Hg2Cl2 (see mercury(I) chloride). The name derives from Greek ''kalos'' (beautiful) and ''melas'' (black) because it turns black on reaction with ammonia. This was known to alchemists. Calomel ...
, a form of mercury. It was removed from most powders in 1954 when it was shown to cause "pink disease" (
acrodynia Acrodynia is a medical condition which occurs due to mercury poisoning. The condition of pain and dusky pink discoloration in the hands and feet is due to exposure or ingesting of mercury. It was known as Pink Disease (due to these symptoms) be ...
), a form of mercury poisoning. Teething toys have a long history. In England in the 17th–19th centuries, a ''coral'' meant a teething toy made of coral, ivory, or bone, often mounted in silver as the handle of a rattle. A museum curator has suggested that these substances were used as sympathetic magic, and that the animal bone could symbolize animal strength to help the child cope with pain.


See also

*
Tooth eruption Tooth eruption is a process in tooth development in which the teeth enter the mouth and become visible. It is currently believed that the periodontal ligament plays an important role in tooth eruption. The first human teeth to appear, the deciduo ...
* Deciduous teeth *
Permanent teeth Permanent teeth or adult teeth are the second set of teeth formed in diphyodont mammals. In humans and old world simians, there are thirty-two permanent teeth, consisting of six maxillary and six mandibular molars, four maxillary and four mand ...
* Dentition


References


External links


NHS Choices Birth to Five Planner
Teething
NHS Choices Health A–Z
Teething * {{Tooth development Infancy Pediatrics Teeth